As around 10 were arrested in violent clashes with police in 20, England fan was injured.
England supporters hurled bottles , while was returned by police in riot equipment using stun grenades.
A pool of blood was left to the street.
While others were awakened one by a person into a police van with hands behind their backs, he was spotted receiving therapy in the back of an ambulance.
Authorities were unable to confirm how many arrests have been made.
The scenes erupted just before 7pm local time after an afternoon of drinking for supporters who had descended on the city ahead of their teams European Qualifier against the Czech Republic.
Countless enthusiasts took at the Old Town of the city, chanting and singing.
There had been little trouble, together with police involvement restricted to telling enthusiasts to remove flags, until night dropped.
But since bottles were pelted in officers, a recorded warning has been performed in English caution them tocomply with the law and that face coverings and pyrotechnics are prohibited.
As missiles continued to be thrown, czech police advanced, firing stun grenades as lovers were forced back through a small archway.
About 10 guys were pinned into a corner and made to lie down face, while another was seen being hauled on the floor nearby as officers.
England fans purchased tickets for Friday nights battle, even though more are thought to have travelled.
The overdue kick-off period of 8.45pm along with the towns party standing contributed to fears of a repeat of dreadful scenes observed on recent trips to Amsterdam, Dortmund and Porto.
The fixture also surfaced with a day of mourning to the country singer and travelling fans have been told to be respectful of mourners.
Ahead of the game, the Football Association asked supporters toreport which fool should they visit anti-social behavior, while police urged those moving to the game not toembarrass themselves.
Deputy chief constable Mark Roberts, the National Police Chiefs Councils football policing lead, stated Pragues a beautiful city. Go, enjoy it, it is an absolutely fantastic place. We have got a team that is worth so there is lots of things to go and 21, supporting and celebrating.
Just dont embarrass yourself or anyone else from drinking to excess and acting in a way where you will wind up on film or in print the next day.

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